Carbamyl Derivatives of Acetylcholinesterase
نویسندگان
چکیده
منابع مشابه
Carbamyl derivatives of acetylcholinesterase.
It has recently been shown that carbamyl derivatives of acetylcholinesterase can be obtained by the reaction of the enzyme with dimethylcarbamyl fluoride, dimethylcarbamyl choline, and carbamyl choline (1). These substances inhibit the enzyme slowly and once inhibited, the enzyme recovers activity slowly upon dilution. The rate of recovery is the same when the inhibitor is either dimethylcarbam...
متن کاملSynthesis and biological evaluation of thiophene derivatives as acetylcholinesterase inhibitors.
A series of new thiophene derivatives has been synthesized using the Gewald protocol. The acetylcholinesterase inhibition activity was assayed according to Ellman's method using donepezil as reference. Some of the compounds were found to be more potent inhibitors than the reference. 2-(2-(4-(4-Methoxyphenyl)piperazin-1-yl)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (IIId) showe...
متن کاملPorphyrin derivatives as inhibitors for acetylcholinesterase from Drosophila melanogaster
The cure for Alzheimer's disease (AD) is still unknown. According to Cholinergic hypothesis, Alzheimer's disease is caused by the reduced synthesis of the neurotransmitter, Acetylcholine. Regional cerebral blood flow can be increased in patients with Alzheimer's disease by Acetylcholinesterase (AChE) inhibitors. In this regard, Tetraphenylporphinesulfonate (TPPS), 5,10,15,20- Tetrakis (4-sulfon...
متن کاملXanthenedione derivatives, new promising antioxidant and acetylcholinesterase inhibitor agents.
Natural and synthetic xanthone derivatives are well-known for their ability to act as antioxidants and/or enzyme inhibitors. This paper aims to present a successful synthetic methodology towards xanthenedione derivatives and the study of their aromatization to xanthones. Additionally their ability to reduce Fe(III), to scavenge DPPH radicals and to inhibit AChE was evaluated. The results demons...
متن کاملStudy of carbamyl phosphate-ornithine transcarbamylase.
The enzyme carbamyl phosphate-ornithine transcarbamylase, which catalyzes the synthesis of citrulline from ornithine plus carbamyl phosphate, has been partially purified from rat liver by means of heat treatment and ethanol fractionation (1). Krebs et al. (2) were able to demonstrate the arsenolysis of citrulline in a number of tissues and, by using sheep liver mitochondria, were able to purify...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1961
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)64204-8